If you change the graphics card, then depending on what type of graphics card you upgrade to (eithe PCI or PCI-e) then you might need to change your whole system.
For example if your system has a PCI graphics card at the moment then you can ONLY upgrade using another PCI graphics card and the same priciple goes for PCI-e.
Bare in mind that all the high end graphics cards these days use the PCI-e standard as it's faster than PCI.
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